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فرط الحساسية تجاه المادة الفعالة أو أي من المكونات الأخرى للدواء.Systemic infections needs to be dealt with concomitantly with or maybe prior to commencing therapy with mitoxantrone.NPCs have been incubated with lentiviruses made up of Oprl1 shRNA for 12h, then the medium was replaced with new m